When did USANA start working on what would become InCelligence? 

When Dr. Wentz first started feeding cells with various plant compounds, that’s when the foundations of InCelligence really started coming into play. From there to here is not necessarily a big shift. But it’s a continuing evolution in our understanding of how cellular processes work and the role that nutrients and plant-based biomolecules — various molecules from plants — play in supporting good cell-to-cell communication.

What sets InCelligence apart?

Three things set it apart. Number one is the actual targets we’re hitting, and number two is that multiple studies have come back showing these new ingredients actually activate these targets. The third piece is that we are able to carefully select which processes to turn on and off.

We’re hitting key targets that actually have a crucial role in foundations of good health. For example, NF-kB — a cell-signaling pathway—allows for modulating healthy inflammatory responses. Normal inflammation is a common occurrence in our busy lives today, popping up from things such as exercise. Supporting a healthy inflammatory response helps your body to maintain optimal health.

The second is that studies have actually observed that the new ingredients activate cell-signaling pathways: NF-kB, mTOR, NRF2, and PPAR. They can show they’ve impacted PPAR gamma signaling in some way, which also plays a role in healthy cellular communication and in supporting normal, healthy glucose and lipid metabolism.

Lastly, we really will be able to select key pathways to activate with the right messenger molecules; interestingly, many of these messengers are from healthy foods. This will only get more and more sophisticated as we continue our research.

Why are the antioxidants produced in our cells more powerful than those we take into our bodies?

The antioxidants we take in from the outside are limited by their ability to deal with one free radical at a time. This is effective and useful, but allows for quenching free radicals in a dose-dependent manner. Once an exogenous antioxidant — one from outside the body — has dealt with a free radical, either they have to be regenerated themselves, or we need another exogenous antioxidant.

Our endogenous antioxidants — the ones made in our cells — in many cases are actually enzymes, and they can process thousands of chemical reactions in as quick as one second. So it’s not a one-shot deal. Free radicals can keep coming at an antioxidant enzyme like superoxide dismutase and the enzyme just keeps disarming them.

How important is the cellular renewal process triggered within our cells?

There’s been quite a lot of excitement generated around mTOR and this target that has the ability to, first and foremost, process old mitochondria and take those parts and make new mitochondria.

That’s important because, first, mitochondria are the power centers of our cells. They produce ATP so we can fuel whatever needs to happen. Secondly, mitochondria generate, within themselves, a huge amount of free radicals. And every mitochondria will leak these free radicals into the cellular environment ever so slightly. As the mitochondria age, the membranes break down more and more, much as an old fence starts to become unstable and develop holes.

So free radicals will leave the mitochondria, and this can damage cellular components we call organelles — tiny cellular organs. As a result, once those mitochondria get old there can be significant damage to the cell. By being able to replace old mitochondria that are leaking free radicals at high rates, essentially what you’ve done is maintained health in the cell.

InCelligence proactively triggers natural responses. Why is that better than just waiting for them to occur naturally?

If we go back to Paleolithic times, when humans had more variety of plant foods in their diets , the high number of select plant molecules ingested triggered a large number of protective biochemical processes, many of which the medical sciences are still learning about. This was a good thing. It promoted signaling in our bodies that was very helpful to our health. With USANA InCelligence, which contains key plant molecules that activate the pathways we previously talked about, what we’re really doing is returning to a time when these beneficial processes were stimulated more frequently than lots of people get these days due to poor diets.

Bottom line, what does the Science of InCelligence mean to current and future users of USANA products?

The Science of InCelligence means we’re going to get better and better, and be at the forefront of science of nutrition. We will be able to tap into multiple targets to optimise cellular nutrition and function — which will have far-reaching effects, reaching into our bodies for the best possible health outcomes.
You can find the product of this cutting-edge nutritional science here if you want to try it for yourself or find more information!

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It started in 1992 with the USANA^® Essentials—antioxidants in optimal doses—and continues to Olivol^® and self-preserving skin care and Nutritional Hybrid Technology and the True Health Assessment and USANA MySmartFoods. And we’re missing almost as many as we listed.

Who are the people behind USANA’s expertise:

Kevin Spelman

The PhD that follows Kevin Spelman’s name already says a lot. Those three letters represent a rarified level of knowledge. But painting a full picture of the expertise of USANA’s executive vice president of research and development requires much more.

Kevin Spelman, PhD, post-doctoral fellow at the National Institutes of Health, Marie Curie fellow in the European Union, former advisor to the White House Commission of Complementary and Alternative Medicine, publisher of 27 scientific papers, and 30-year veteran of the natural-products industry.

We sat down with Dr. Spelman to find out more about him, the amazing team of scientists at USANA, and what innovation means to him.

When did you know you wanted to be a scientist?

Early on, as a young child. I can’t give you an age. I was always interested in the way things worked. I was especially interested in biology, the wonderment of life. This sometimes got me in trouble with my parents. I once built an ant farm in the bathtub when I was quite young.

What was it about biology that sparked some inspiration for you?

Life is juicy. For me, chemistry was fascinating, but too dry. Biology gave chemistry meaning to me. I’m just fascinated by life, whether it’s social structures, the xenohormetic physiological cues from our surrounding environment, the molecular pathways of our bodies’ web of life, or the network nature of ecology. I’m fascinated by all of it, particularly on a molecular level. I tend to think on a molecular level, as well as from the 30,000-foot view.

Why did you want to focus on nutrition?

My own health, actually. I was frequently ill as a child. In my early 20s, I started really getting interested in what type of foods I was eating and the impact it was having on me. It made a huge difference in my health and made me understand that there was much more to health than what our medical community knew.

You have so much amazing experience. What made you choose USANA?

Honestly, Dr. Wentz. Seeing that USANA really is based in science—and everybody says that—but USANA really came from a scientist’s conception of wanting to improve human health. After hearing Dr. Wentz’ story, he won me over.

What do you think sets USANA apart scientifically?

The quality of our R&D team. We have some very thoughtful and critically thinking scientists in the R&D department that really want the very best for every product that goes out. I’ve been in natural products for 30 years. It is unfortunate that R&D teams are more than occasionally an illusory part of supplement companies. Our R&D team is real, hardcore, and well-funded. We spend a lot of resources getting everything just right. The fact that we have pharmaceutical-grade GMPs was another thing that won me over. I thought to myself, “USANA is really serious about their quality control.” Our QC is just spot-on in terms of pharmaceutical GMPs. I think those are the things that really set us apart.

Why is it so important to ground our products in scientific research and not just chase trends?

We’re not a member of the molecule of the month club. We want something real. We want something that’s going to last. We want something that’s really going to improve people’s health over long-term use. Trends often don’t do that.

Rachel A. Brewer, PhD, senior scientist specializing in microbiome research

How did you start to add to the R&D team?

We started with a preexisting base of excellent scientists, so that was an important piece. Then we hunted for the brightest minds we could find. Since we already had a good foundation with some highly experienced and intelligent scientists, and then we added a microbiome expert to our R&D team, we have generated an extraordinary and exciting innovative potential.

What does Dr. Wentz’ vision mean to you?

It means that he’s really got his heart and his mind in the right place. He was innovative early on, in a way that nobody else was, and he took a chance, a risk, and it turned out to be the right thing to do. I think that’s one of the things I keep having to remind myself and the team is that we have to push our comfort level. Innovation is stepping into the unknown. We are not interested in “me too” products.

Why is innovation so important to you and to USANA?

I think because our Associates see that we are leading the way in nutritional science and they expect that. And the only way we’re going to continue to lead the way is to be innovative and to step into uncharted territory. It is my goal that USANA continues to disrupt the natural products industry by putting out novel products based on cutting-edge research in the nutritional sciences. We have everything in place to be 15 strides ahead of our competition.

Continuing the Legacy

It’s time to lengthen that timeline, because we aren’t done innovating.

We really just can’t help ourselves. Right now, in a building on the west side of Salt Lake City, another major evolution is in the works. And it’s a big one.

Do we know what it is? Sure we do. Have we been sworn to secrecy about it? You could say that. But we can tell you when it will be unveiled: August 25, 2016, at the USANA International Convention. See you there!

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